%0 Journal Article %A ZOLTÁN BARÁTH %A RITA RADICS %A GABRIELLA SPENGLER %A IMRE OCSOVSZKI %A MASAMI KAWASE %A NOBORU MOTOHASHI %A YOSHIAKI SHIRATAKI %A ANAMIK SHAH %A JÓZSEF MOLNÁR %T Multidrug Resistance Reversal by 3-Formylchromones in Human Colon Cancer and Human mdr1 Gene-transfected Mouse Lymphoma Cells %D 2006 %J In Vivo %P 645-649 %V 20 %N 5 %X Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the 3-formylchromones. The total polar surface areas and the ground state dipole moments of the molecules are presumed to play a key role in the multidrug resistance-reversing effect. The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells. Copyright © 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved %U https://iv.iiarjournals.org/content/invivo/20/5/645.full.pdf