TY - JOUR T1 - Multidrug Resistance Reversal by 3-Formylchromones in Human Colon Cancer and Human <em>mdr1</em> Gene-transfected Mouse Lymphoma Cells JF - In Vivo JO - In Vivo SP - 645 LP - 649 VL - 20 IS - 5 AU - ZOLTÁN BARÁTH AU - RITA RADICS AU - GABRIELLA SPENGLER AU - IMRE OCSOVSZKI AU - MASAMI KAWASE AU - NOBORU MOTOHASHI AU - YOSHIAKI SHIRATAKI AU - ANAMIK SHAH AU - JÓZSEF MOLNÁR Y1 - 2006/09/01 UR - http://iv.iiarjournals.org/content/20/5/645.abstract N2 - Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the 3-formylchromones. The total polar surface areas and the ground state dipole moments of the molecules are presumed to play a key role in the multidrug resistance-reversing effect. The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells. Copyright © 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -