TY - JOUR T1 - Tumour-specific Cytotoxicity and MDR-reversal Activity of Dihydropyridines JF - In Vivo JO - In Vivo SP - 637 LP - 643 VL - 20 IS - 5 AU - HELGA ENGI AU - HIROSHI SAKAGAMI AU - MASAMI KAWASE AU - ALPESH PARECHA AU - DINESH MANVAR AU - HIMANSHU KOTHARI AU - PRITI ADLAKHA AU - ANAMIK SHAH AU - NOBORU MOTOHASHI AU - IMRE OCSOVSZKI AU - JOSEPH MOLNÁR Y1 - 2006/09/01 UR - http://iv.iiarjournals.org/content/20/5/637.abstract N2 - The ability of 41 1,4-diphenyl-1,4-dihydropyridine derivatives to inhibit the transport activity of P-glycoprotein were studied by flow cytometry in a multidrug-resistant human colon cancer cell line (COLO320) and in human mdr1 gene-transfected mouse lymphoma cells (L 5178 Y). The cytotoxicities of these compounds were also examined against human normal and cancer cell lines. The majority of the tested compounds proved to be effective inhibitors of rhodamine 123 outward transport, but their cytotoxicities were not negligible. Some dihydropyridine derivatives displayed cytotoxic activity against four human oral tumour cell lines and against three normal human oral cell lines. There was no clear-cut relationship between the multidrug-resistance activity or cytotoxicity and the chemical structures of the compounds. New ring substituents could prevent the oxidation of the ring of the aromatic compound. Copyright © 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -