RT Journal Article
SR Electronic
T1 Oxidative Stress and Oral Mucosal Diseases: An Overview
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 289
OP 296
DO 10.21873/invivo.11474
VO 33
IS 2
A1 NICOLA SARDARO
A1 FEDORA DELLA VELLA
A1 MARIA ANGELA INCALZA
A1 DARIO DI STASIO
A1 ALBERTA LUCCHESE
A1 MARIA CONTALDO
A1 CLAUDIA LAUDADIO
A1 MASSIMO PETRUZZI
YR 2019
UL http://iv.iiarjournals.org/content/33/2/289.abstract
AB Background: Reactive oxygen species (ROS) and free radicals are physiologically produced during cellular metabolism. When their balance is disrupted in favor of ROS, a condition called oxidative stress occurs. Oxidative stress represents a widespread phenomenon involved in several pathological conditions. The aim of the present review was to report current knowledge on oxidative stress related to oral mucosal diseases. Materials and Methods: Articles from 2000 to 2018 were selected for relevance, validity and quality, from results obtained in PubMed, MEDLINE and Google Scholar using the following search terms: oxidative stress and oral lichen, oral pemphigus, aphthous stomatitis, oral leukoplakia, oral cancer, oral squamous cell carcinoma and oral carcinoma. All articles were independently screened for eligibility by the authors. Results: This narrative review integrates extensive information from all relevant published studies focusing on oxidative stress in oral mucosal diseases. We outline the pathogenetic function of oxidative stress in the most frequent inflammatory, potentially malignant and malignant diseases of the oral mucosa and provide detailed findings from human research. Conclusion: Although variability in findings between individual studies exists, it justifies the conclusion that oxidative stress is a significant process in the oral mucosal diseases pathogenesis.