TY - JOUR T1 - Diclofenac in the Management of <em>E. coli</em> Urinary Tract Infections JF - In Vivo JO - In Vivo SP - 613 LP - 619 VL - 20 IS - 5 AU - KAUSHIKI MAZUMDAR AU - NOTON KUMAR DUTTA AU - SUJATA G. DASTIDAR AU - NOBORU MOTOHASHI AU - YOSHIAKI SHIRATAKI Y1 - 2006/09/01 UR - http://iv.iiarjournals.org/content/20/5/613.abstract N2 - E. coli is the main agent of uncomplicated urinary tract infections (UTIs) and accounts for more than 85% of recurrent cystitis and at least 35% of recurrent pyelonephritis. Despite the widespread availability of antibiotics, UTIs remain the most common bacterial infection in the human population. It is currently advised that the clinical administration of antibiotics against the pathogenic bacteria should be prohibitted due to the emergence of multidrug resistant (MDR) bacterial strains. Therefore, newer and more effective antimicrobials are in demand to treat such cases. One hundred and thirty six urine samples were collected from UTI patients. E. coli was isolated from 85 samples, out of which 33% were resistant to common antibiotics. The isolates were decreasingly resistant to ampicillin, tobramycin, augmentin, nalidixic acid, cefuroxime, nitrofurantoin, kanamycin, pipemidic acid, chloramphenicol, cefotaxime, cefamendol, ofloxacin, ceftizoxime, norfloxacin and amikacin. The anti-inflammatory drug diclofenac exhibited significant antibacterial activity against common bacterial strains both in vitro and in vivo. The present work was conducted to evaluate the in vitro inhibitory effect of this drug on the clinically isolated strains of E. coli in hospitals. All the isolates were sensitive to diclofenac, with MIC values ranging from 5-50 μg/mL. The MIC90 value of the drug was 25 μg/mL. Therefore, it may be suggested that diclofenac has the capacity to treat UTI caused by E. coli. Copyright © 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -