RT Journal Article
SR Electronic
T1 Radiation-induced Oral Mucositis in Brazilian Patients: Prevalence and Associated Factors
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 605
OP 609
DO 10.21873/invivo.11517
VO 33
IS 2
A1 PEREIRA, IGOR FIGUEIREDO
A1 FIRMINO, RAMON TARGINO
A1 MEIRA, HENRIQUE CORTES
A1 DO EGITO VASCONCELOS, BELMIRO CAVALCANTI
A1 DE SOUZA NORONHA, VLADIMIR REIMAR AUGUSTO
A1 SANTOS, VAGNER RODRIGUES
YR 2019
UL http://iv.iiarjournals.org/content/33/2/605.abstract
AB Aim: To determine the prevalence of radiation-induced oral mucositis (OM) and associated factors. Patients and Methods: A cross-sectional retrospective study was performed at a reference dental care center. The medical records of patients submitted to radiotherapy for the treatment of head and neck cancer were used to collect clinical and demographic variables. The data were submitted to descriptive analysis and multivariate Poisson regression with robust variance [p<0.05; 95% confidence intervaI (CI)]. Results: Four hundred and thirteen patients were analyzed. The mean age was 55±14 years. The prevalence of OM in the overall sample was 41.9% and was higher among males (78.2%). The following variables were significantly associated with the outcome: radiation dose [prevalence ratio (PR)= 1.04; 95% CI=1.02-1.06]; concomitant chemotherapy (PR=1.48, 95% CI=1.05-2.08); oral candidiasis (PR=1.97, 95% CI=1.44-2.68); and osteoradionecrosis (PR=1.51, 95% CI=1.10-2.06). Conclusion: Radiation-induced OM was associated with radiation dose, concomitant chemotherapy, oral candidiasis and osteoradionecrosis. The rate of OM underscores the importance of adequate oral care prior to treatment for head and neck cancer.