RT Journal Article
SR Electronic
T1 The Role of Serum Nestin in Diagnosis and Prognosis of Breast Cancer: A Prospective Observational Study
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2399
OP 2403
DO 10.21873/invivo.13707
VO 38
IS 5
A1 KOLIA, AIKATERINI
A1 FROUNTZAS, MAXIMOS
A1 LIATSOU, EFSTATHIA
A1 SAMELIS, GEORGE
A1 ZAGOURI, FLORA
A1 ZOGRAFOS, GEORGE C.
A1 GAZOULI, MARIA
A1 MICHALOPOULOS, NIKOLAOS V.
YR 2024
UL http://iv.iiarjournals.org/content/38/5/2399.abstract
AB Background/Aim: The molecular classification of breast cancer has enabled targeted therapy for specific molecular subtypes. Nestin, which has been studied for its role in oncogenesis, could contribute to this direction. This study aimed to investigate the differences between serum nestin levels and molecular profiling, as well as histopathological tumor types, in women who underwent surgery for breast cancer. Patients and Methods: Women who underwent surgery for breast cancer at the Breast Unit of the 1st Propaedeutic Department of Surgery, Hippocration General Hospital, National and Kapodistrian University of Athens were prospectively included. Patients’ demographic data were recorded and serum nestin levels were measured. Molecular biomarker analysis was performed, as well as histopathologic assessment. Results: Seventy patients were included in the analysis. Among patients with breast cancer, 93% were estrogen receptor (ER) positive, 91% were progesterone receptor (PR) positive, and 43% were human epidermal growth factor receptor 2 (HER2) positive. Ki67 was expressed in 16% of patients and p53 was expressed in 32% of patients. Invasive ductal carcinoma was diagnosed in 80% of patients, with 44% of tumors classified as T1 and 46% as T2. Additionally, 43% were G1 and 56% were N0, while 34% were N1. No statistically significant difference was observed between serum nestin levels and ER, PR, HER2, Ki67, and p53 expression. Furthermore, no difference was observed between serum nestin levels and breast cancer histological type, size, N-stage, and grading. Conclusion: The diagnostic and prognostic role of circulating nestin for breast cancer was not confirmed and no correlation with immunohistochemistry results was observed. Thus, the necessity of larger prospective studies is enhanced.