TY - JOUR T1 - Comparison of PNA Clamping-assisted Fluorescence Melting Curve Analysis and PNA Clamping in Detecting <em>EGFR</em> Mutations in Matched Tumor Tissue, Cell Block, Pleural Effusion and Blood of Lung Cancer Patients With Malignant Pleural Effusion JF - In Vivo JO - In Vivo SP - 595 LP - 603 DO - 10.21873/invivo.11516 VL - 33 IS - 2 AU - SANG HOON JEON AU - HYUNG WOO KIM AU - BIT NA KIM AU - NAHYEON KANG AU - CHANG DONG YEO AU - CHAN KWON PARK AU - YOUNG KYOON KIM AU - YOON HO LEE AU - TAE-JUNG KIM AU - KYO YOUNG LEE AU - SUG HYUNG LEE AU - JONG Y. PARK AU - MI SUN PARK AU - HYEON WOO YIM AU - SEUNG JOON KIM Y1 - 2019/03/01 UR - http://iv.iiarjournals.org/content/33/2/595.abstract N2 - Background/Aim: This study compared the efficacy of PANAMutyper™, a novel technology that integrates PNAClamp™ and PANA S-Melting™, and PNAClamp™ alone for the detection of EGFR mutations in lung cancer patients. Materials and Methods: PANAMutyper™ and PNAClamp™ were used to assess the EGFR mutation status in tissue, cell block, pleural effusion, and blood samples of 90 lung cancer patients with malignant pleural effusion. Results: PANAMutyper™ detected more EGFR mutations than PNAClamp™, especially in body fluids (pleural effusion and serum). Patients with additional EGFR mutations detected using PANAMutyper™ had a favorable response to EGFR-tyrosine kinase inhibitor (TKI) treatment. Conclusion: The diagnostic performance of PANAMutyper™ was superior to that of PNAClamp™ for the detection of EGFR mutations. It was also better at identifying lung cancer patients with malignant pleural effusion who were likely to benefit from EGFR-TKI treatment. ER -