RT Journal Article
SR Electronic
T1 A Phase II Clinical Study on Relapsed Malignant Gliomas Treated with Electro-hyperthermia
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 721
OP 724
VO 20
IS 6A
A1 GIAMMARIA FIORENTINI
A1 PETROS GIOVANIS
A1 SUSANNA ROSSI
A1 PATRIZIA DENTICO
A1 RAFFAELE PAOLA
A1 GINA TURRISI
A1 PAOLO BERNARDESCHI
YR 2006
UL http://iv.iiarjournals.org/content/20/6A/721.abstract
AB The purpose of this study was to evaluate the activity and toxicity of electro-hyperthermia (ET) on relapsed malignant glioma patients. Twelve patients with histologically diagnosed malignant glioma entered the study. Eight patients had glioblastoma multiforme, two had anaplastic astrocytoma grade III and two had anaplastic oligodendroglioma. All patients were pre-treated with temozolamide-based chemotherapy and radiotherapy. Hyperthermia with short radiofrequency waves of 13.56 MHz was applied using a capacitive coupling technique keeping the skin surface at 20°C. The applied power ranged between 40-150 Watts and the calculated average equivalent temperature in the tumours was above 40°C for more than 90% of the treatment duration. One complete remission and 2 partial remission were achieved, with a response rate of 25%. The median duration of response was 10 months (range 4-32). The median survival of the entire patient population was 9 months, with 25% survival rate at 1 year. ET appears to have some effectiveness in adults with relapsed malignant glioma. Copyright © 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved