RT Journal Article
SR Electronic
T1 Personalizing Prophylactic Radiotherapy for Hip Heterotopic Ossification: An AMSTAR-2 Compliant Review of Meta-analyses
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1530
OP 1536
DO 10.21873/invivo.13603
VO 38
IS 4
A1 GALIETTA, ERIKA
A1 GAIANI, LUCA
A1 GIANNINI, CLAUDIO
A1 SAMBRI, ANDREA
A1 BUWENGE, MILLY
A1 MACCHIA, GABRIELLA
A1 DEODATO, FRANCESCO
A1 CILLA, SAVINO
A1 STRIGARI, LIDIA
A1 ARCELLI, ALESSANDRA
A1 FIORE, MICHELE
A1 CAMMELLI, SILVIA
A1 DE PAOLIS, MASSIMILIANO
A1 MORGANTI, ALESSIO GIUSEPPE
YR 2024
UL http://iv.iiarjournals.org/content/38/4/1530.abstract
AB Background/Aim: Heterotopic ossification (HO) is a common complication following total hip arthroplasty. Various prophylactic treatments have been proposed, including radiotherapy (RT). This review summarizes the evidence from meta-analyses on the efficacy of RT in preventing hip HO. Materials and Methods: A literature search was conducted on PubMed. The quality of the meta-analyses was assessed using the AMSTAR-2 tool. Results: Seven meta-analyses were included. One meta-analysis reported a significant reduction in HO occurrence after RT compared to the control group. Comparing RT and non-steroidal anti-inflammatory drugs, one and two meta-analyses showed significantly greater efficacy of RT in preventing severe HO and better outcomes in patients receiving drugs, respectively. Regarding RT settings, the postoperative and preoperative RT were each supported by one meta-analysis. Furthermore, two meta-analyses showed an advantage of multi-fractionated RT over single fraction RT. The overall confidence rate of the meta-analyses was moderate, low, and critically low in one, three, and three meta-analyses, respectively. Conclusion: RT is a confirmed prophylactic intervention for HO. However, the precise optimization of timing, dosage, and fractionation requires elucidation. Future research should focus on the development of predictive models through large-scale data collection and advanced analytics to refine individualized treatment strategies and assess RT comparative effectiveness with drugs.