RT Journal Article
SR Electronic
T1 Relationship Between Renal Dysfunction and Oral Mucositis in Patients Undergoing Concurrent Chemoradiotherapy for Pharyngeal Cancer: A Retrospective Cohort Study
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 183
OP 189
DO 10.21873/invivo.11457
VO 33
IS 1
A1 HIROFUMI MIZUNO
A1 HISATAKA MIYAI
A1 AYA YOKOI
A1 TERUMASA KOBAYASHI
A1 CHIAKI INABU
A1 TAKAYUKI MARUYAMA
A1 DAISUKE EKUNI
A1 NOBUYOSHI MIZUKAWA
A1 SHIN KARIYA
A1 KAZUNORI NISHIZAKI
A1 YOSHIHIRO KIMATA
A1 MANABU MORITA
YR 2019
UL http://iv.iiarjournals.org/content/33/1/183.abstract
AB Background/Aim: The aim of this retrospective cohort study was to investigate the association between renal dysfunction (RD) and the development of oral mucositis (OM) in patients undergoing concurrent chemoradiotherapy (CCRT) for pharyngeal cancer including radiation to the oral cavity. Patients and Methods: Of 130 patients diagnosed as having pharyngeal cancer who received CCRT at the Okayama University Hospital Head and Neck Cancer Center, 44 were finally selected. Results: During the observation period, 24 (54.5%) patients experienced severe OM (grade 3). The Cox proportional hazards regression model demonstrated that RD (hazard ratio(HR)=2.45, 95% confidence interval(CI)=1.067-6.116, p=0.035) and nasopharynx/oropharynx as center of the irradiated area (HR=2.56, 95% CI=1.072-5.604, p=0.034) were significantly associated with the incidence of severe OM (grade 3). Conclusion: In patients with pharyngeal cancer treated with CCRT including radiation to the oral cavity, RD at baseline can be a risk factor for developing severe OM.