RT Journal Article
SR Electronic
T1 Membranous Nephropathy as a Paraneoplastic Syndrome in Cancer of Unknown Primary
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1503
OP 1508
DO 10.21873/invivo.13598
VO 38
IS 3
A1 KAIRA, KYOICHI
A1 AMANO, HIROAKI
A1 IMAI, HISAO
A1 OKADA, HIROKAZU
A1 KAGAMU, HIROSHI
YR 2024
UL http://iv.iiarjournals.org/content/38/3/1503.abstract
AB Background/Aim: Membranous nephropathy (MN) is a nephrotic syndrome with both idiopathic and secondary etiologies. The mechanism of cancer-associated MN is presumed to involve the immunological production of antibodies against a tumor antigen, although little is known about the detailed mechanism. Lung cancer is a major neoplasm associated with cancer-associated MN. However, the simultaneous occurrence of secondary MN in patients with cancer of unknown primary (CUP) remains unclear. Case Report: Here, we present a case of secondary MN in a 72-year-old female as a paraneoplastic syndrome in CUP. Thoracic radiotherapy up to a total of 60 Gy was initially performed on the right subclavian and mediastinal lymph nodes. Computed tomography revealed marked shrinking of these lymph nodes, and the secondary MN also improved without any symptoms. Conclusion: The presence of proteinuria in patients with CUP suggests the possibility of secondary MN as a rare differential diagnosis.