RT Journal Article
SR Electronic
T1 Homozygosity at the C677T of the <em>MTHFR</em> Gene is Associated with Increased Breast Cancer Risk in the Turkish Population
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 889
OP 893
VO 19
IS 5
A1 UGUR DELIGEZER
A1 E. EBRU AKISIK
A1 NEJAT DALAY
YR 2005
UL http://iv.iiarjournals.org/content/19/5/889.abstract
AB Background: Folate deficiency is implicated in cancer development. Single nucleotide polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene can modulate the effect of folate. In this case-controlled study, a possible effect of the common MTHFR C677T (ala→val) polymorphism on breast cancer susceptibility in Turkish patients was investigated. Materials and Methods: Polymorphism analysis was performed by melting curve analysis. Results: The variant allele valine (677T) was more frequent among the patients (30.1%) than in controls (23.9%). This difference was weakly significant (p=0.046; OR=1.37) and due to a significantly higher frequency of the valine homozygotes (677TT) among the patients (12.1% vs. 5.4%; p=0.013, OR=2.5). Among the patients diagnosed at more than 40 years of age, a more pronounced association of the valine homozygotes with breast cancer risk was observed (p=0.009; OR=3.3). Conclusion: Homozygosity for the low-activity C677T genotype (TT) may represent a genetic determinant increasing breast cancer risk. Copyright © 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved