%0 Journal Article %A ANDREA VLASTOS FRANZÉN %A KARIN TEGERSTEDT %A DANA HOLLÄNDEROVA %A JITKA FORSTOVA %A TORBJÖRN RAMQVIST %A TINA DALIANIS %T Murine Polyomavirus-VP1 Virus-like Particles Immunize against some Polyomavirus-induced Tumours %D 2005 %J In Vivo %P 323-326 %V 19 %N 2 %X The ability of murine polyomavirus (MPyV)-VP1 virus-like particles (MPyV-VLPs) to immunize against MPyV tumour outgrowth was investigated. Non-immunized and mice immunized three times were challenged with MPyV or non-MPyV tumours and followed for tumour outgrowth. MPyV-VLP immunization abrogated outgrowth of some, but not all, tested MPyV tumours and delayed the outgrowth of a non-MPyV tumour to some extent. However, when mice were irradiated prior to tumour challenge to avoid an unspecific immune response, protection was MPyV-specific. In conclusion, VLP immunization for prevention of viral infection could also contribute to immune-protection against some tumours induced by the corresponding virus. %U https://iv.iiarjournals.org/content/invivo/19/2/323.full.pdf