RT Journal Article
SR Electronic
T1 Kelch-like Protein 11 (KLHL11) Antibodies in Children With Seizures of Undetermined Cause
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 351
OP 357
DO 10.21873/invivo.13445
VO 38
IS 1
A1 TZARTOS, JOHN
A1 PECHLIVANIDOU, MARIA
A1 BOSVELI, DESPOINA
A1 NINOU, ELPINICKIE
A1 YUCEER, HANDE
A1 YALCIN, BEYZANUR
A1 KUCUKALI, CEM ISMAIL
A1 TUZUN, ERDEM
A1 TZARTOS, SOCRATES
A1 TURKDOGAN, DILSAD
YR 2024
UL http://iv.iiarjournals.org/content/38/1/351.abstract
AB Background/Aim: Kelch-like protein 11 (KLHL11)-antibody may be found in paraneoplastic neurological disorders presenting with epileptic seizures. The aim of this study was to investigate the prevalence and clinical significance of KLHL11-antibody in epilepsy. Patients and Methods: Sera of 42 pediatric and 59 adult patients with seizures of undetermined cause were screened using a cell-based assay. Results: KLHL11-antibody was found in three of 168 control patients with paraneoplastic neurological disorders and four pediatric patients (4-8-year-old, 2 boys/2 girls) with seizures of unknown cause presenting with myoclonic-atonic epilepsy, generalized epilepsy or childhood epilepsy with centrotemporal spikes. In these four cases, seizures continued for 2-7 months, responded promptly and favorably to conventional anti-seizure drugs and did not recur in follow-up durations ranging between 2-5 years. Patients had normal brain MRI findings and motor-mental development before and after seizures. KLHL11-antibody was not detected in adult epilepsy patients with undetermined cause, MOG antibody-positive patients and healthy controls. Conclusion: KLHL11-antibody may be detected in pediatric epilepsy patients with a relatively benign disease course.