PT  - JOURNAL ARTICLE
AU  - TZARTOS, JOHN
AU  - PECHLIVANIDOU, MARIA
AU  - BOSVELI, DESPOINA
AU  - NINOU, ELPINICKIE
AU  - YUCEER, HANDE
AU  - YALCIN, BEYZANUR
AU  - KUCUKALI, CEM ISMAIL
AU  - TUZUN, ERDEM
AU  - TZARTOS, SOCRATES
AU  - TURKDOGAN, DILSAD
TI  - Kelch-like Protein 11 (KLHL11) Antibodies in Children With Seizures of Undetermined Cause
AID  - 10.21873/invivo.13445
DP  - 2024 Jan 01
TA  - In Vivo
PG  - 351--357
VI  - 38
IP  - 1
4099  - http://iv.iiarjournals.org/content/38/1/351.short
4100  - http://iv.iiarjournals.org/content/38/1/351.full
SO  - In Vivo2024 Jan 01; 38
AB  - Background/Aim: Kelch-like protein 11 (KLHL11)-antibody may be found in paraneoplastic neurological disorders presenting with epileptic seizures. The aim of this study was to investigate the prevalence and clinical significance of KLHL11-antibody in epilepsy. Patients and Methods: Sera of 42 pediatric and 59 adult patients with seizures of undetermined cause were screened using a cell-based assay. Results: KLHL11-antibody was found in three of 168 control patients with paraneoplastic neurological disorders and four pediatric patients (4-8-year-old, 2 boys/2 girls) with seizures of unknown cause presenting with myoclonic-atonic epilepsy, generalized epilepsy or childhood epilepsy with centrotemporal spikes. In these four cases, seizures continued for 2-7 months, responded promptly and favorably to conventional anti-seizure drugs and did not recur in follow-up durations ranging between 2-5 years. Patients had normal brain MRI findings and motor-mental development before and after seizures. KLHL11-antibody was not detected in adult epilepsy patients with undetermined cause, MOG antibody-positive patients and healthy controls. Conclusion: KLHL11-antibody may be detected in pediatric epilepsy patients with a relatively benign disease course.