PT  - JOURNAL ARTICLE
AU  - PINTÉR, OLIVÉR
AU  - MUCSI, ILONA
AU  - MOLNAR, JOSEPH
TI  - <em>In Vitro</em> Antiproliferation in Prostate Cancer Cell Lines with Cytostatics and Combinations with Resistance Modifiers
DP  - 2005 Jan 01
TA  - In Vivo
PG  - 253--259
VI  - 19
IP  - 1
4099  - http://iv.iiarjournals.org/content/19/1/253.short
4100  - http://iv.iiarjournals.org/content/19/1/253.full
SO  - In Vivo2005 Jan 01; 19
AB  - The treatment of prostate cancer in an advanced state is still unsatisfactory. In the event of the ineffectiveness of total androgen blockade (TAB) therapy, cytostatic administration may be attempted. In this study, we modelled the drugs used in practice on human prostate cancer cell lines. Studies aimed at decreasing multidrug resistance were performed on PC-3 cells. With the use of various cytostatics, the cell proliferation-inhibiting effects were measured under in vitro conditions on human prostate cancer cell lines LNCaP-FGC and PC-3. Under the given experimental conditions, the examined cytostatics exhibited antiproliferative effects on each of the investigated cell lines. Our results indicate that it is not necessary to wait until the development of a hormone-resistant state. In the studies on the PC-3 cell line, we did not find a multidrug-resistant efflux activity responsible for the resistance of the tumour. Copyright © 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved