RT Journal Article
SR Electronic
T1 Expression of Cytokeratins 8 and 18 on Mallory Body and Oval Cell in Rats during Hepatic Fibrosis
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 769
OP 775
VO 19
IS 4
A1 JEONG, WON-IL
A1 JEONG, DA-HEE
A1 DO, SUN-HEE
A1 YANG, HAI-JIE
A1 HONG, IL-HWA
A1 CHANG, SEONG-JOON
A1 YUAN, DONG-WEI
A1 KWAK, DONG-MI
A1 KIM, TAE-HWAN
A1 KIM, YOO-KYEONG
A1 LEE, IN-SEON
A1 JEONG, KYU-SHIK
YR 2005
UL http://iv.iiarjournals.org/content/19/4/769.abstract
AB Background: The aim of this study was to determine the induction and distribution of Mallory body (MB) and oval cells in carbon-tetrachloride (CCl4)-induced rat liver fibrosis. Materials and Methods: MBs and oval cells expressing cytokeratins (CKs) 8 and 18 were monitored by immunohistochemistry and immunoblotting. Results: MBs were mainly detected within hepatocytes near the fibrotic areas, and oval cells were located along or in the fibrotic areas. Both MBs and oval cells increased in size and number in the development of fibrosis. At cirrhotic liver, most of the oval cells were located in the fibrous septa and around newly formed bile ductules. Moreover, as hepatic injuries developed into fibrosis, a much more prominent single band of CK18 was detected. Conclusion: The occurrence and distribution of MB and oval cells in CCl4-induced rat liver fibrosis are reported. This represents the first CCl4 experimental in vivo model of MB induction, which will be useful for further investigations on the pathogenesis of MB. Copyright © 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved