TY - JOUR T1 - Expression of JNK Interacting Protein JIP-1 is Down-regulated in Liver from Mouse Embryos with a Disrupted Insulin-like Growth Factor II Gene JF - In Vivo JO - In Vivo SP - 643 LP - 648 VL - 18 IS - 5 AU - LISA ROHBE AU - MIA LARSSON AU - ANNA RISING AU - STEFAN GRIP AU - JASON BURNS AU - WILHELM ENGSTRÖM Y1 - 2004/09/01 UR - http://iv.iiarjournals.org/content/18/5/643.abstract N2 - JNK interacting Protein 1 (JIP-1) is a pivotal scaffolding protein in the JNK signalling pathway. Its expression pattern in murine tissue indicates that JIP-1 has a role in the regulation of different cellular events. By examining the JIP-1 expression in transgenic mice that were heterozygous for a functional insulin-like growth factor II (igf-2) gene, it was possible to show that an abrogated igf-2 expression was followed by a decreased transcription of the JIP-1 gene. This pattern was consistent through different litters, which suggests that the up- or down-regulation of JIP-1 may well be part of the intracellular mediation of IGF II induced messages. Copyright © 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -