PT  - JOURNAL ARTICLE
AU  - LISA ROHBE
AU  - MIA LARSSON
AU  - ANNA RISING
AU  - STEFAN GRIP
AU  - JASON BURNS
AU  - WILHELM ENGSTRÖM
TI  - Expression of JNK Interacting Protein JIP-1 is Down-regulated in Liver from Mouse Embryos with a Disrupted Insulin-like Growth Factor II Gene
DP  - 2004 Sep 01
TA  - In Vivo
PG  - 643--648
VI  - 18
IP  - 5
4099  - http://iv.iiarjournals.org/content/18/5/643.short
4100  - http://iv.iiarjournals.org/content/18/5/643.full
SO  - In Vivo2004 Sep 01; 18
AB  - JNK interacting Protein 1 (JIP-1) is a pivotal scaffolding protein in the JNK signalling pathway. Its expression pattern in murine tissue indicates that JIP-1 has a role in the regulation of different cellular events. By examining the JIP-1 expression in transgenic mice that were heterozygous for a functional insulin-like growth factor II (igf-2) gene, it was possible to show that an abrogated igf-2 expression was followed by a decreased transcription of the JIP-1 gene. This pattern was consistent through different litters, which suggests that the up- or down-regulation of JIP-1 may well be part of the intracellular mediation of IGF II induced messages. Copyright © 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved