PT  - JOURNAL ARTICLE
AU  - VANESSA V. SANTOS
AU  - TANIA S. FRÖDE
AU  - YARA S. MEDEIROS
TI  - Analysis of the Temporal Events in Blood and Tissues Following Fecal Peritonitis in Mice
DP  - 2004 Sep 01
TA  - In Vivo
PG  - 571--576
VI  - 18
IP  - 5
4099  - http://iv.iiarjournals.org/content/18/5/571.short
4100  - http://iv.iiarjournals.org/content/18/5/571.full
SO  - In Vivo2004 Sep 01; 18
AB  - Background: The kinetics of systemic responses triggered by bacterial peritonitis were analysed in the blood, bronchoalveolar lavage (BAL) and several organs. Materials and Methods: The murine model of cecal ligation and puncture was employed. The parameters were analysed at different periods of time (4 to 72 h). Results: Fecal peritonitis triggered a progressive, but not significant, decline of blood leukocytes between 4 and 6 h, becoming significant at 24 to 48 h (p<0.05). This profile was closely associated with the enhancement of leukocytes both in the abdomen (p<0.05) and in the BAL (p<0.05). A significant abdominal exudation was detected between 4 and 72 h (p<0.01), whereas maximal growth of aerobic bacteria in the blood and lungs was observed 24 and 72 h after. Maximal exudation in the studied tissues occurred at different time points (heart=24 h, spleen and kidney=48 h, liver and lung=72 h). Conclusion: Using this model, evidence of sepsis can be easily measured in different body systems. Copyright © 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved