RT Journal Article
SR Electronic
T1 Slowly Progressive Bone Marrow Metastasis of Gastric Cancer Followed-up Without Treatment
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1389
OP 1393
DO 10.21873/invivo.13222
VO 37
IS 3
A1 HIROTAKA SUTO
A1 YUMIKO INUI
A1 ATSUO OKAMURA
YR 2023
UL http://iv.iiarjournals.org/content/37/3/1389.abstract
AB Background/Aim: Bone marrow metastasis (BMM) of gastric cancer (GC) is complicated by disseminated intravascular coagulation syndrome (DIC), which is more prominent in poorly differentiated carcinoma. This is one of the first case reports of a slowly progressing BMM of GC after approximately 1 year of follow-up without treatment. Case Report: A 72-year-old woman underwent total gastrectomy and splenectomy for GC in February 2012. The pathological diagnosis was that of a moderately differentiated adenocarcinoma. Five years later in December 2017, she developed anemia; however, its cause remained unknown. Due to worsening of the anemia, the patient visited the Kakogawa Central City Hospital in October 2018. Bone marrow biopsy revealed an infiltration of caudal type homeobox 2-positive cancer cells, and our diagnosis was BMM of GC. There was no DIC. The incidence of BMM is high in well- or moderately differentiated breast cancer but rarely causes DIC. Conclusion: As with breast cancer, in moderately differentiated cancer cells, BMM of GC may progress slowly after the appearance of symptoms without causing DIC.