TY - JOUR T1 - Slowly Progressive Bone Marrow Metastasis of Gastric Cancer Followed-up Without Treatment JF - In Vivo JO - In Vivo SP - 1389 LP - 1393 DO - 10.21873/invivo.13222 VL - 37 IS - 3 AU - HIROTAKA SUTO AU - YUMIKO INUI AU - ATSUO OKAMURA Y1 - 2023/05/01 UR - http://iv.iiarjournals.org/content/37/3/1389.abstract N2 - Background/Aim: Bone marrow metastasis (BMM) of gastric cancer (GC) is complicated by disseminated intravascular coagulation syndrome (DIC), which is more prominent in poorly differentiated carcinoma. This is one of the first case reports of a slowly progressing BMM of GC after approximately 1 year of follow-up without treatment. Case Report: A 72-year-old woman underwent total gastrectomy and splenectomy for GC in February 2012. The pathological diagnosis was that of a moderately differentiated adenocarcinoma. Five years later in December 2017, she developed anemia; however, its cause remained unknown. Due to worsening of the anemia, the patient visited the Kakogawa Central City Hospital in October 2018. Bone marrow biopsy revealed an infiltration of caudal type homeobox 2-positive cancer cells, and our diagnosis was BMM of GC. There was no DIC. The incidence of BMM is high in well- or moderately differentiated breast cancer but rarely causes DIC. Conclusion: As with breast cancer, in moderately differentiated cancer cells, BMM of GC may progress slowly after the appearance of symptoms without causing DIC. ER -