PT - JOURNAL ARTICLE AU - ANGELIKI CHORTI AU - CHAROULA ACHILLA AU - DESPOINA TSALKATIDOU AU - MOYSIS MOYSIDIS AU - ANGELIKI CHEVA AU - ANTHOULA CHATZIKYRIAKIDOU AU - THEODOSIOS PAPAVRAMIDIS TI - A Pilot Study of the Association <em>VDR</em> Polymorphisms With Primary Hyperparathyroidism AID - 10.21873/invivo.13186 DP - 2023 May 01 TA - In Vivo PG - 1111--1116 VI - 37 IP - 3 4099 - http://iv.iiarjournals.org/content/37/3/1111.short 4100 - http://iv.iiarjournals.org/content/37/3/1111.full SO - In Vivo2023 May 01; 37 AB - Background/Aim: Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder characterized by autonomous parathyroid hormone (PTH) production from one or more parathyroid glands and hypocalcemia. Vitamin D through its receptor is a principal regulator of parathyroid glands function. VDR gene polymorphisms, which affect the expression or structure of VDR protein, may be involved in the genetic pathogenesis of PHPT. The aim of this study was to investigate the role of FokI, ApaI, TaqI, and BsmI VDR gene polymorphisms as genetic predisposing factors for PHPT. Patients and Methods: Fifty unrelated patients with sporadic PHPT and an equal number of corresponding ethnicity, sex and age range healthy volunteers were enrolled in the study. Genotyping was performed with polymerase chain reaction and restriction fragment length polymorphism assay. Results: Statistically significant difference was observed in TaqI genotype distribution between PHPT patients and controls, while no association was detected for the other studied polymorphisms. Conclusion: TaqI TT and TC genotypes may be associated with PHPT risk in Greek population. Further independent studies are needed to replicate and validate the role of VDR TaqI polymorphism in PHPT predisposition.