PT  - JOURNAL ARTICLE
AU  - MICHAEL E. BRANDT
AU  - GERHARD R. F. KRUEGER
AU  - GUANYU WANG
AU  - L. MAXIMILIAN BUJA
TI  - Feed-forward and Feedback Mechanisms in a Dynamic Model of Human T Cell Development and Regulation
DP  - 2004 Jul 01
TA  - In Vivo
PG  - 465--470
VI  - 18
IP  - 4
4099  - http://iv.iiarjournals.org/content/18/4/465.short
4100  - http://iv.iiarjournals.org/content/18/4/465.full
SO  - In Vivo2004 Jul 01; 18
AB  - We describe a computational model of human T cell regulatory dynamics. We used this model to simulate changes in T cell pool numbers and for studying feedback and feed-forward responses in and among these pools. The pools identified were the bone marrow stem cell compartment, early and late thymocyte compartments and the peripheral compartment of mature T lymphocytes. Simulated data showed variable intercompartmental strengths indicative of a range of sensitivities to feedback regulation and respective variable feed-forward responses. The results compare well to known clinical and experimental data, rendering the computational model a good basis for further research in T cell development and regulation.