RT Journal Article
SR Electronic
T1 Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 307
OP 314
VO 25
IS 3
A1 VINCENT C. LOMBARDI
A1 KATHRYN S. HAGEN
A1 KENNETH W. HUNTER
A1 JOHN W. DIAMOND
A1 JULIE SMITH-GAGEN
A1 WEI YANG
A1 JUDY A. MIKOVITS
YR 2011
UL http://iv.iiarjournals.org/content/25/3/307.abstract
AB Background: The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease. Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS. Materials and Methods: Using Luminex multi-analyte profiling technology, we measured cytokine and chemokine values in the plasma of XMRV-infected CFS patients and compared these data to those of healthy controls. Analysis was performed using the Gene Expression Pattern Analysis Suite and the Random Forest tree classification algorithm. Results: This study identifies a signature of 10 cytokines and chemokines which correctly identifies XMRV/CFS patients with 93% specificity and 96% sensitivity. Conclusion: These data show, for the first time, an immunological pattern associated with XMRV/CFS.