TY - JOUR T1 - Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature JF - In Vivo JO - In Vivo SP - 307 LP - 314 VL - 25 IS - 3 AU - VINCENT C. LOMBARDI AU - KATHRYN S. HAGEN AU - KENNETH W. HUNTER AU - JOHN W. DIAMOND AU - JULIE SMITH-GAGEN AU - WEI YANG AU - JUDY A. MIKOVITS Y1 - 2011/05/01 UR - http://iv.iiarjournals.org/content/25/3/307.abstract N2 - Background: The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease. Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS. Materials and Methods: Using Luminex multi-analyte profiling technology, we measured cytokine and chemokine values in the plasma of XMRV-infected CFS patients and compared these data to those of healthy controls. Analysis was performed using the Gene Expression Pattern Analysis Suite and the Random Forest tree classification algorithm. Results: This study identifies a signature of 10 cytokines and chemokines which correctly identifies XMRV/CFS patients with 93% specificity and 96% sensitivity. Conclusion: These data show, for the first time, an immunological pattern associated with XMRV/CFS. ER -