PT  - JOURNAL ARTICLE
AU  - LOMBARDI, VINCENT C.
AU  - HAGEN, KATHRYN S.
AU  - HUNTER, KENNETH W.
AU  - DIAMOND, JOHN W.
AU  - SMITH-GAGEN, JULIE
AU  - YANG, WEI
AU  - MIKOVITS, JUDY A.
TI  - Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature
DP  - 2011 May 01
TA  - In Vivo
PG  - 307--314
VI  - 25
IP  - 3
4099  - http://iv.iiarjournals.org/content/25/3/307.short
4100  - http://iv.iiarjournals.org/content/25/3/307.full
SO  - In Vivo2011 May 01; 25
AB  - Background: The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease. Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS. Materials and Methods: Using Luminex multi-analyte profiling technology, we measured cytokine and chemokine values in the plasma of XMRV-infected CFS patients and compared these data to those of healthy controls. Analysis was performed using the Gene Expression Pattern Analysis Suite and the Random Forest tree classification algorithm. Results: This study identifies a signature of 10 cytokines and chemokines which correctly identifies XMRV/CFS patients with 93% specificity and 96% sensitivity. Conclusion: These data show, for the first time, an immunological pattern associated with XMRV/CFS.