PT  - JOURNAL ARTICLE
AU  - RADES, DIRK
AU  - KRISTIANSEN, CHARLOTTE
AU  - SCHILD, STEVEN E.
AU  - JANSSEN, STEFAN
TI  - Short Communication: Results of a Consensus Conference on Radiotherapy for Brain and Bone Metastases Within the Interreg-Project TreaT
AID  - 10.21873/invivo.13158
DP  - 2023 Mar 01
TA  - In Vivo
PG  - 894--897
VI  - 37
IP  - 2
4099  - http://iv.iiarjournals.org/content/37/2/894.short
4100  - http://iv.iiarjournals.org/content/37/2/894.full
SO  - In Vivo2023 Mar 01; 37
AB  - Background/Aim: Differences between radiotherapy for metastases in Northern Germany and Southern Denmark were previously identified, which led to a consensus conference. Patients and Methods: A consensus conference was held between three centers to harmonize radiotherapy regimens for bone and brain metastases. Results: Centers agreed on 1×8 Gy for painful bone metastases in patients with poor or intermediate survival prognoses and 10×3 Gy for favorable-prognosis patients. For complicated bone metastases, 5-6×4 Gy was preferred for poor-prognosis, 10×3 Gy for intermediate-prognosis, and longer-course radiotherapy for favorable-prognosis patients. For ≥5 brain metastases, centers agreed on whole-brain irradiation (WBI) with 5×4 Gy in poor-prognosis and longer-course regimens in other patients. For single brain lesions and patients with 2-4 lesions and intermediate/favorable prognoses, fractionated stereotactic radiotherapy (FSRT) or radiosurgery were recommended. No consensus was reached for 2-4 lesions in poor-prognosis patients; two centers preferred FSRT, one center WBI. Preferred radiotherapy regimens were similar for different age groups including elderly and very elderly patients, but age-specific survival scores were recommended. Conclusion: The consensus conference was successful, since harmonization of radiotherapy regimens was achieved for 32 of 33 possible situations.