TY - JOUR T1 - Republication: <em>In Vitro</em> and <em>Ex Vivo</em> Analysis of Collagen Foams for Soft and Hard Tissue Regeneration JF - In Vivo JO - In Vivo SP - 320 LP - 328 DO - 10.21873/invivo.13082 VL - 37 IS - 1 AU - OLE JUNG AU - MIKE BARBECK AU - LU FAN AU - FABIAN KORTE AU - CUIFENG ZHAO AU - RUMEN KRASTEV AU - SVEN PANTERMEHL AU - XIN XIONG Y1 - 2023/01/01 UR - http://iv.iiarjournals.org/content/37/1/320.abstract N2 - Background/Aim: The aim of this study was the conception, production, material analysis and cytocompatibility analysis of a new collagen foam for medical applications. Materials and Methods: After the innovative production of various collagen sponges from bovine sources, the foams were analyzed ex vivo in terms of their structure (including pore size) and in vitro in terms of cytocompatibility according to EN ISO 10993-5/-12. In vitro, the collagen foams were compared with the established biomaterials cerabone and Jason membrane. Materials cerabone and Jason membrane. Results: Collagen foams with different compositions were successfully produced from bovine sources. Ex vivo, the foams showed a stable and long-lasting primary structure quality with a bubble area of 1,000 to 2,000 μm2. In vitro, all foams showed sufficient cytocompatibility. Conclusion: Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams. ER -