RT Journal Article SR Electronic T1 Republication: In Vitro and Ex Vivo Analysis of Collagen Foams for Soft and Hard Tissue Regeneration JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 320 OP 328 DO 10.21873/invivo.13082 VO 37 IS 1 A1 OLE JUNG A1 MIKE BARBECK A1 LU FAN A1 FABIAN KORTE A1 CUIFENG ZHAO A1 RUMEN KRASTEV A1 SVEN PANTERMEHL A1 XIN XIONG YR 2023 UL http://iv.iiarjournals.org/content/37/1/320.abstract AB Background/Aim: The aim of this study was the conception, production, material analysis and cytocompatibility analysis of a new collagen foam for medical applications. Materials and Methods: After the innovative production of various collagen sponges from bovine sources, the foams were analyzed ex vivo in terms of their structure (including pore size) and in vitro in terms of cytocompatibility according to EN ISO 10993-5/-12. In vitro, the collagen foams were compared with the established biomaterials cerabone and Jason membrane. Materials cerabone and Jason membrane. Results: Collagen foams with different compositions were successfully produced from bovine sources. Ex vivo, the foams showed a stable and long-lasting primary structure quality with a bubble area of 1,000 to 2,000 μm2. In vitro, all foams showed sufficient cytocompatibility. Conclusion: Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams.