RT Journal Article
SR Electronic
T1 Etiological Agents of Lower Respiratory Tract Infections in Japanese Children
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 67
OP 72
VO 18
IS 1
A1 NUMAZAKI, KEI
A1 CHIBA, SHUNZO
A1 UMETSU, MASAO
A1 TANAKA, TORU
A1 YOSHIMURA, HIDEATSU
A1 KUNIYA, YOSHINORI
A1 MIURA, JUNICHI
A1 ADACHI, NORIAKI
A1 UKAE, SUSUMU
A1 MORI, TOSHIHIKO
A1 UEDA, DAISUKE
A1 HOTSUBO, TOMOYUKI
A1 SATO, TOSHIYA
YR 2004
UL http://iv.iiarjournals.org/content/18/1/67.abstract
AB To investigate the etiology of pediatric community-acquired pneumonia and bronchitis, we conducted a prospective, population-based study covering the total population <15 years of age in 16 municipalities in Hokkaido, Japan, during the period of April 2000 to March 2001. Chest radiographs were available for all cases (n=921; 398 as pneumonia and 523 as bronchitis) and paired sera for serologic assays were available for more than half of the cases. The following specimens were also collected : nasopharyngeal swabs for viral, bacteriological, mycoplasmal and chlamydial studies, blood for serology and blood culture. The children were then followed-up on days 3, 7 and 14. Specific infecting organisms were identified in a total of 853 (92.6%) out of 921 patients (398 cases of pneumonia and 523 cases of bronchitis) including 205 with mixed infection as follows: Mycoplasma pneumoniae, 252 (27.4%) patients; respiratory syncytial (RS) virus, 188 (20.4%); influenza A virus, 110 (11.9%); Streptococcus pneumoniae, 95 (10.3%); Haemophilus influenzae, 90 (9.8%); Haemophilus parainfluenzae, 35 (3.8%); Staphylococcus aureus, 29 (3.1%); adenovirus, 27 (2.9%); Moraxella catarrhalis, 12 (1.3%); Pseudomonas aeruginosa, 7 (0.8%); Chlamydia pneumoniae, 6 (0.7%); and other agents, 2 (0.2%). Mycoplasma infections were seen even in patients less than 5 years and RS and influenza A virus infections in patients more than 5 years of age. The importance of M. pneumoniae and RS virus in the etiology of lower respiratory infections in Japanese children was confirmed. Copyright © 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved