RT Journal Article
SR Electronic
T1 Effect of Oligomeric Proanthocyanidin on the Antioxidant Status and Lung Function of Patients with Chronic Obstructive Pulmonary Disease
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 753
OP 758
DO 10.21873/invivo.11304
VO 32
IS 4
A1 LU, MENG-CHUN
A1 YANG, MEI-DUE
A1 LI, PING-CHUN
A1 FANG, HSIN-YUAN
A1 HUANG, HUI-YING
A1 CHAN, YIN-CHING
A1 BAU, DA-TIAN
YR 2018
UL http://iv.iiarjournals.org/content/32/4/753.abstract
AB Background/Aim: Evidence exists that oxidative stress and oxidative damage play a pivotal role in chronic obstructive pulmonary disease (COPD). Oligomeric proanthocyanidins (OPCs) extracted from grape seeds have been shown to exhibit antioxidant capabilities greater than those of vitamin C and E. The objective of this study was to evaluate the effects of OPCs on antioxidant status and lung function in patients with COPD. Patients and Methods: Patients were supplemented with 150 mg/day OPC (n=13) orally or with a placebo (n=14) for 8 weeks in a randomized double-blind clinical design. Changes in anthropometric values, lung function, oxidative state, and lipid profiles were assessed after OPC or placebo treatment for 8 weeks. Results: The results showed that OPC supplementation significantly reduced the concentration of malondialdehyde, superoxide dismutase, and total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio. The concentration of HDL-C significantly increased in the OPC-treated group. The plasma triglyceride, TC and low-density lipoprotein cholesterol values and the activities of catalase and glutathione peroxidase also decreased, but did not significantly differ between the OPC- and placebo-treated groups. Lung function was not significantly different between the two groups after 8 weeks. Conclusion: OPC supplementation was effective in increasing the antioxidant capacity, in addition to improving the lipid profiles in patients with COPD.