TY - JOUR T1 - The Significance of the D-Dimer Level as a Prognostic Marker for Survival and Treatment Outcomes in Patients With Stage IV Colorectal Cancer JF - In Vivo JO - In Vivo SP - 440 LP - 444 DO - 10.21873/invivo.13097 VL - 37 IS - 1 AU - MASATSUNE SHIBUTANI AU - SHINICHIRO KASHIWAGI AU - TATSUNARI FUKUOKA AU - YASUHITO ISEKI AU - HIROAKI KASASHIMA AU - KIYOSHI MAEDA Y1 - 2023/01/01 UR - http://iv.iiarjournals.org/content/37/1/440.abstract N2 - Background/Aim: Predictive markers for survival and therapeutic efficacy in stage IV colorectal cancer have not been established. As described in our previous report, D-dimer levels may have potential utility as an indicator of cancer activity. The present study evaluated the significance of the D-dimer level as a marker for the survival and treatment outcomes in patients with stage IV colorectal cancer. Patients and Methods: A total of 34 patients who underwent surgery for stage IV colorectal cancer between February 2017 and October 2019 were enrolled. The D-dimer level was measured using a blood sample obtained at the first visit to our hospital. Results: The median preoperative D-dimer level was 1.2 μg/ml (range=0.5-41.0 μg/ml). We divided patients into two groups using a D-dimer level of 2.0 μg/ml as the cut-off value based on receiver operating characteristic curve analysis. The group with a high-D-dimer-level had a significantly shorter overall survival than that with a low D-dimer level. Progression-free survival after first-line chemotherapy tended to be better in those with a low D-dimer level group than in the high-D-dimer-level group. Conclusion: The preoperative D-dimer level may be a useful indicator for survival and chemotherapeutic outcome in patients with stage IV colorectal cancer. ER -