TY - JOUR T1 - Insulin-like Growth Factor Binding Protein 1 (IGFBP-1) in Vaginal Fluid in Pregnancy JF - In Vivo JO - In Vivo SP - 37 LP - 42 VL - 18 IS - 1 AU - IDA VOGEL AU - HENNING GRØNBAEK AU - POUL THORSEN AU - ALLAN FLYVBJERG Y1 - 2004/01/01 UR - http://iv.iiarjournals.org/content/18/1/37.abstract N2 - Objective: To examine vaginal insulin-like growth factor binding protein 1 (IGFBP-1) as a marker of preterm delivery, amniotic fluid leakage or vaginal infection. Materials and Methods: The material consisted of a nested case-control study (67 with idiopathic preterm delivery and 406 randomly selected women with term deliveries) from a prospective cohort of 2,846 women. Results: Vaginal npIGFBP-1 was weakly associated with preterm delivery. Elevated npIGFBP-1 gave an increased risk of preterm delivery (OR 2.8 [1.4-6.7]). Elevated IGFBP-1 provided a sensitivity of 13% at a false-positive rate of 4.4% in a low-risk population. When adjusting for other covariates associated with preterm delivery the association between npIGFBP-1 and preterm delivery disappeared; there was an interaction between alcohol consumption and npIGFBP-1. Conclusion: The current study found vaginal npIGFBP-1 to be weakly associated with gestational age at delivery. However, in this study the association may potentially be explained by alcohol consumption. Copyright © 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -