@article {AMATO2052, author = {ANTONINO AMATO and GORDON MCVIE and GIOVANNI PAGANELLI and PIER LUIGI CARRIERO and ROBERTO CIANNI and GIUSEPPE MARIA ETTORRE}, title = {In Vivo Models for the Performance and Safety of BAT-90, a Novel 90-Yttrium-based Internal Radiotherapy Platform}, volume = {36}, number = {5}, pages = {2052--2060}, year = {2022}, doi = {10.21873/invivo.12931}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: BAT-90 is an innovative active implantable device designed for the irradiation of unresectable tumors (e.g., liver cancer) or surgical tumor beds, based on the combination of Yttrium-90 beta-emitting microspheres and a tissue adhesive hydrogel, currently used in cardio-vascular surgery. The rationale behind BAT-90 is to localize the Yttrium-90 activity on the administration site, while minimizing its body dispersion. Materials and Methods: The effective induction of necrosis in the target injection area was tested in a pig liver model, whereas the safety of BAT-90 was assessed and demonstrated in biocompatibility tests for acute systemic toxicity, intracutaneous reactivity, delayed hypersensitivity and subcutaneous implantation. Results: BAT-90 administration induced necrosis into the target site, while the safety experiments in the treated animals highlighted results very similar to the controls. Conclusion: BAT-90 could be considered as a safe and innovative treatment option for inoperable solid tumors of the liver.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/36/5/2052}, eprint = {https://iv.iiarjournals.org/content/36/5/2052.full.pdf}, journal = {In Vivo} }