RT Journal Article
SR Electronic
T1 Increasing Seizure Activity During Radiation Treatment for High-grade Gliomas - Final Results of a Prospective Interventional Study
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2308
OP 2313
DO 10.21873/invivo.12961
VO 36
IS 5
A1 RADES, DIRK
A1 WITTELER, JASPAR
A1 TRILLENBERG, PETER
A1 OLBRICH, DENISE
A1 SCHILD, STEVEN E.
A1 TVILSTED, SØREN
A1 KJAER, TROELS W.
YR 2022
UL http://iv.iiarjournals.org/content/36/5/2308.abstract
AB Background/Aim: Little is known regarding seizures during radiotherapy for brain tumors. This prospective study investigated seizure activity in patients irradiated for high-grade gliomas. Patients and Methods: Using a seizure diary, progression of seizure activity was evaluated in 22 patients receiving chemoradiation for grade III (n=1) or IV (n=21) gliomas. Progression was defined as increased frequency of any and/or generalized seizures (>50%) or increased anti-epileptic medication (≥25%). Patients’ satisfaction with the diary was assessed using a questionnaire (six scales of 1-7 points). Uni- and multivariable analyses were performed including baseline seizure activity, age, sex, resection, tumor site, performance score, and history of epilepsy/seizures. Results: Ten patients (45%) experienced progression of seizure activity during their radiotherapy course, mainly due to increased seizure frequency (nine patients=41%). Mean values of patients’ satisfaction scores ranged between 3.92 and 4.92 points. Conclusion: Radiotherapy of high-grade gliomas can increase seizure activity. Patients require close monitoring to initiate or adjust anti-epileptic medication.