<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">RADES, DIRK</style></author><author><style face="normal" font="default" size="100%">WITTELER, JASPAR</style></author><author><style face="normal" font="default" size="100%">TRILLENBERG, PETER</style></author><author><style face="normal" font="default" size="100%">OLBRICH, DENISE</style></author><author><style face="normal" font="default" size="100%">SCHILD, STEVEN E.</style></author><author><style face="normal" font="default" size="100%">TVILSTED, SØREN</style></author><author><style face="normal" font="default" size="100%">KJAER, TROELS W.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Increasing Seizure Activity During Radiation Treatment for High-grade Gliomas - Final Results of a Prospective Interventional Study</style></title><secondary-title><style face="normal" font="default" size="100%">In Vivo</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2022-09-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">2308-2313</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/invivo.12961</style></doi><volume><style face="normal" font="default" size="100%">36</style></volume><issue><style face="normal" font="default" size="100%">5</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: Little is known regarding seizures during radiotherapy for brain tumors. This prospective study investigated seizure activity in patients irradiated for high-grade gliomas. Patients and Methods: Using a seizure diary, progression of seizure activity was evaluated in 22 patients receiving chemoradiation for grade III (n=1) or IV (n=21) gliomas. Progression was defined as increased frequency of any and/or generalized seizures (&gt;50%) or increased anti-epileptic medication (≥25%). Patients’ satisfaction with the diary was assessed using a questionnaire (six scales of 1-7 points). Uni- and multivariable analyses were performed including baseline seizure activity, age, sex, resection, tumor site, performance score, and history of epilepsy/seizures. Results: Ten patients (45%) experienced progression of seizure activity during their radiotherapy course, mainly due to increased seizure frequency (nine patients=41%). Mean values of patients’ satisfaction scores ranged between 3.92 and 4.92 points. Conclusion: Radiotherapy of high-grade gliomas can increase seizure activity. Patients require close monitoring to initiate or adjust anti-epileptic medication.</style></abstract></record></records></xml>