RT Journal Article SR Electronic T1 Clinical Significance of Mean Corpuscular Volume in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 2371 OP 2378 DO 10.21873/invivo.12969 VO 36 IS 5 A1 HAYATO WATANABE A1 KAZUKI KANO A1 ITARU HASHIMOTO A1 HIDEAKI SUEMATSU A1 TORU AOYAMA A1 TAKANOBU YAMADA A1 TAKASHI OGATA A1 YASUSHI RINO A1 TAKASHI OSHIMA YR 2022 UL http://iv.iiarjournals.org/content/36/5/2371.abstract AB Background/Aim: To clarify the clinical significance of measuring the mean corpuscular volume (MCV) of red blood cells before applying neoadjuvant chemotherapy (NAC) in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who will receive NAC followed by curative resection. Patients and Methods: We retrospectively investigated 169 eligible patients at the Kanagawa Cancer Center between 2011-2018. The patients were divided into high and low-MCV groups. The cutoff value of the MCV was determined by the maximum χ2 statistic value on the log-rank test and was set at 92.8 fl. Clinicopathological features and outcomes were compared between the two groups. Results: There was no significant association between the MCV and clinicopathological features. Both five-year recurrence-free survival (RFS) and overall survival (OS) in the high-MCV group were significantly poorer than those in the low-MCV group (RFS, p=0.026; OS, p=0.006). On multivariate analysis, a high-MCV was an independent predictive survival factor for RFS [hazard ratio (HR)=1.728; 95% confidence interval (CI)=1.033-2.891; p=0.037] and OS (HR=1.836; 95%CI=1.002-3.365; p=0.049). Conclusion: Measurement of the MCV before NAC may be a useful prognostic biomarker in patients with locally advanced ESCC who will receive NAC followed by curative resection.