RT Journal Article
SR Electronic
T1 The Prognostic Significance of Preoperative Anemia in Gastric Cancer Patients
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2314
OP 2322
DO 10.21873/invivo.12962
VO 36
IS 5
A1 TOMOHIRO KUNISHIGE
A1 KAZUHIRO MIGITA
A1 SOHEI MATSUMOTO
A1 KOHEI WAKATSUKI
A1 HIROSHI NAKADE
A1 SATOKO AOKI
A1 SHINTARO MIYAO
A1 TAKANARI TATSUMI
A1 AKINORI TSUJIMOTO
A1 MASAYUKI SHO
YR 2022
UL http://iv.iiarjournals.org/content/36/5/2314.abstract
AB Background/Aim: This study aimed to investigate the prognostic significance of preoperative anemia in gastric cancer patients. Patients and Methods: The medical records of 801 patients with gastric cancer who underwent gastrectomy at the Nara Medical University hospital, were reviewed. Anemia was defined as a hemoglobin (Hb) level of <10 g/dl. Multivariate analysis was performed to identify prognostic factors. Results: The mean Hb level was 13.1 (SD=2.0). Sixty-four (8.0%) patients were classified into the anemic group. Anemic patients were significantly older than nonanemic patients (p=0.007). Anemia was significantly associated with cardiovascular disease (p=0.041), chronic renal failure (p<0.001), tumor depth (p<0.001), and lymph node metastasis (p=0.001). The overall survival (OS) and cause-specific survival (CSS) rates of anemic patients were significantly lower in comparison to the nonanemic patients (p<0.001). In a subgroup analysis, the OS rate of anemic patients was significantly lower than that of nonanemic patients among patients with stage I and stage II disease. According to a multivariate analysis, preoperative anemia was an independent prognostic factor for OS (p<0.001), but not CSS (p=0.555). The rate of non-cancer deaths among anemic patients was significantly higher than that among nonanemic patients (p<0.001). Conclusion: Preoperative anemia is a simple and reliable predictor of poor prognosis, and it is associated with a higher risk of non-cancer death.