TY - JOUR T1 - Beneficial Effects of Broccoli (<em>Brassica oleracea</em> var <em>italica</em>) By-products in Diet-induced Obese Mice JF - In Vivo JO - In Vivo SP - 2173 LP - 2185 DO - 10.21873/invivo.12943 VL - 36 IS - 5 AU - TÂNIA MARTINS AU - RÚBEN LEITE AU - ANA FILIPA MATOS AU - JOANA SOARES AU - MARIA JOÃO PIRES AU - MARIA DE LURDES PINTO AU - MARIA JOÃO NEUPARTH AU - ANA RITA SEQUEIRA AU - LUÍS FÉLIX AU - CARLOS VENÂNCIO AU - SANDRA MARIZA MONTEIRO AU - BRUNO COLAÇO AU - IRENE GOUVINHAS AU - ANA ISABEL BARROS AU - EDUARDO ROSA AU - PAULA ALEXANDRA OLIVEIRA AU - LUÍS MIGUEL ANTUNES Y1 - 2022/09/01 UR - http://iv.iiarjournals.org/content/36/5/2173.abstract N2 - Background/Aim: Obesity currently affects the whole world, with greater incidence in high-income countries, with vast economic and social costs. Broccoli harvest generates many by-products equally rich in bioactive compounds with potential anti-obesity effects. This study aimed to evaluate the anti-obesity effects of broccoli by-products flour (BF) in obese mice. Materials and Methods: A commercial high-fat diet formulation (representing a Western diet) was used to induce obesity in mice. BF (0.67% or 1.34% weight/weight) was incorporated as a chemoprevention compound into a control and a hypercholesterolemic diet, at two different concentrations, and fed for 14 weeks to C57BL/6J mice. For a therapeutic approach, two groups were fed with the hypercholesterolemic diet for 10 weeks, and then fed with BF-supplemented diets in the last 4 weeks of the study. Results: BF supplementation helped to maintain a lower body weight, reduced adipose tissue accumulation, and enhanced the basal activity of superoxide dismutase and glutathione S-transferase. Although BF supplementation tended to reduce the relative liver weight increased by the Western diet, the differences were not significant. Conclusion: BF appears to have a beneficial effect in preventing weight gain and fat accumulation induced by hypercholesterolemic diets. ER -