RT Journal Article
SR Electronic
T1 Beneficial Effects of Broccoli (Brassica oleracea var italica) By-products in Diet-induced Obese Mice
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2173
OP 2185
DO 10.21873/invivo.12943
VO 36
IS 5
A1 TÂNIA MARTINS
A1 RÚBEN LEITE
A1 ANA FILIPA MATOS
A1 JOANA SOARES
A1 MARIA JOÃO PIRES
A1 MARIA DE LURDES PINTO
A1 MARIA JOÃO NEUPARTH
A1 ANA RITA SEQUEIRA
A1 LUÍS FÉLIX
A1 CARLOS VENÂNCIO
A1 SANDRA MARIZA MONTEIRO
A1 BRUNO COLAÇO
A1 IRENE GOUVINHAS
A1 ANA ISABEL BARROS
A1 EDUARDO ROSA
A1 PAULA ALEXANDRA OLIVEIRA
A1 LUÍS MIGUEL ANTUNES
YR 2022
UL http://iv.iiarjournals.org/content/36/5/2173.abstract
AB Background/Aim: Obesity currently affects the whole world, with greater incidence in high-income countries, with vast economic and social costs. Broccoli harvest generates many by-products equally rich in bioactive compounds with potential anti-obesity effects. This study aimed to evaluate the anti-obesity effects of broccoli by-products flour (BF) in obese mice. Materials and Methods: A commercial high-fat diet formulation (representing a Western diet) was used to induce obesity in mice. BF (0.67% or 1.34% weight/weight) was incorporated as a chemoprevention compound into a control and a hypercholesterolemic diet, at two different concentrations, and fed for 14 weeks to C57BL/6J mice. For a therapeutic approach, two groups were fed with the hypercholesterolemic diet for 10 weeks, and then fed with BF-supplemented diets in the last 4 weeks of the study. Results: BF supplementation helped to maintain a lower body weight, reduced adipose tissue accumulation, and enhanced the basal activity of superoxide dismutase and glutathione S-transferase. Although BF supplementation tended to reduce the relative liver weight increased by the Western diet, the differences were not significant. Conclusion: BF appears to have a beneficial effect in preventing weight gain and fat accumulation induced by hypercholesterolemic diets.