RT Journal Article
SR Electronic
T1 The Modified Glasgow Prognostic Score and Prognostic Nutritional Index as Prognostic Markers in Patients With Metastatic Breast Cancer Treated With Eribulin
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1854
OP 1859
DO 10.21873/invivo.12903
VO 36
IS 4
A1 SHINYA YAMAMOTO
A1 SHOKO ADACHI
A1 TOMOKO WADA
A1 KAZUTAKA NARUI
A1 AKI KIMURA
A1 MASANORI OSHI
A1 AKIMITSU YAMADA
A1 TOSHIHIRO MISUMI
A1 ITARU ENDO
YR 2022
UL http://iv.iiarjournals.org/content/36/4/1854.abstract
AB Aim: To examine the role of the Modified Glasgow Prognostic Score (mGPS) and Prognostic Nutritional Index (PNI) as prognostic markers for patients with metastatic breast cancer (MBC). Patients and Methods: We investigated the associations of clinico-pathological factors with time-to-treatment failure (TTF) and overall survival (OS) in 110 patients with MBC treated with eribulin. Results: C-Reactive protein >1 mg/dl, albumin <3.5 g/dl, mGPS=2, and PNI <40 were significant predictors of shorter TTF in univariate analyses. PNI <40 remained a significant and independent predictor of shorter TTF in multivariate analyses. De novo tumor, visceral metastases, C-reactive protein >1 mg/dl, albumin <3.5 g/dl, mGPS=2, and PNI <40 were significant predictors of poor OS at the univariate level. A PNI <40 was a significant and independent predictor of poor OS in multivariate analyses. Conclusion: PNI is a reliable predictor of TTF and OS in patients with MBC treated with eribulin.