PT  - JOURNAL ARTICLE
AU  - SHINYA YAMAMOTO
AU  - SHOKO ADACHI
AU  - TOMOKO WADA
AU  - KAZUTAKA NARUI
AU  - AKI KIMURA
AU  - MASANORI OSHI
AU  - AKIMITSU YAMADA
AU  - TOSHIHIRO MISUMI
AU  - ITARU ENDO
TI  - The Modified Glasgow Prognostic Score and Prognostic Nutritional Index as Prognostic Markers in Patients With Metastatic Breast Cancer Treated With Eribulin
AID  - 10.21873/invivo.12903
DP  - 2022 Jul 01
TA  - In Vivo
PG  - 1854--1859
VI  - 36
IP  - 4
4099  - http://iv.iiarjournals.org/content/36/4/1854.short
4100  - http://iv.iiarjournals.org/content/36/4/1854.full
SO  - In Vivo2022 Jul 01; 36
AB  - Aim: To examine the role of the Modified Glasgow Prognostic Score (mGPS) and Prognostic Nutritional Index (PNI) as prognostic markers for patients with metastatic breast cancer (MBC). Patients and Methods: We investigated the associations of clinico-pathological factors with time-to-treatment failure (TTF) and overall survival (OS) in 110 patients with MBC treated with eribulin. Results: C-Reactive protein >1 mg/dl, albumin <3.5 g/dl, mGPS=2, and PNI <40 were significant predictors of shorter TTF in univariate analyses. PNI <40 remained a significant and independent predictor of shorter TTF in multivariate analyses. De novo tumor, visceral metastases, C-reactive protein >1 mg/dl, albumin <3.5 g/dl, mGPS=2, and PNI <40 were significant predictors of poor OS at the univariate level. A PNI <40 was a significant and independent predictor of poor OS in multivariate analyses. Conclusion: PNI is a reliable predictor of TTF and OS in patients with MBC treated with eribulin.