PT  - JOURNAL ARTICLE
AU  - MINAKO INOUE-YURI
AU  - HIRAYUKI ENOMOTO
AU  - ICHIRO WAKABAYASHI
AU  - YUKIHISA YURI
AU  - NOBUHIRO AIZAWA
AU  - NAOTO IKEDA
AU  - TOMOYUKI TAKASHIMA
AU  - AOI FUJIWARA
AU  - RYOTA YOSHIOKA
AU  - SHOKI KAWATA
AU  - KOHEI YOSHIHARA
AU  - SHOGO OTA
AU  - RYOTA NAKANO
AU  - HIDEYUKI SHIOMI
AU  - TAKASHI NISHIMURA
AU  - SHUHEI NISHIGUCHI
AU  - HIROKO IIJIMA
TI  - Modification of the ALBI-PLT Score for the Prediction of High-risk Varices
AID  - 10.21873/invivo.12839
DP  - 2022 May 01
TA  - In Vivo
PG  - 1360--1366
VI  - 36
IP  - 3
4099  - http://iv.iiarjournals.org/content/36/3/1360.short
4100  - http://iv.iiarjournals.org/content/36/3/1360.full
SO  - In Vivo2022 May 01; 36
AB  - Background/Aim: A new scoring system [albumin-bilirubin-platelet (ALBI-PLT) score] was reported for identifying cirrhotic patients without high-risk varices (HRV), and patients with ALBI grade 1 (≤−2.60) and a platelet count over 150×109/l were shown to have a low risk of having HRV. The present study modified the cut-off values of the variables in the ALBI-PLT score. Patients and Methods: Among a total of 338 patients with chronic liver diseases, possible cut-off values of the ALBI score and the platelet count were determined by analyzing the first-half group (training cohort: N=169) with the receiver operating characteristic (ROC) method. The utility of the determined values was evaluated in the second-half group (validation cohort: N=169) and total cohort (N=338). In addition, the utility of the modified cut-off values was evaluated in patients with compensated cirrhosis (cirrhotic cohort: N=87). Results: Possible cut-off values of the ALBI score and platelet count were found to be –2.36 and 114×109/l, respectively. In the training cohort, these cut-off values provided a higher ratio of avoiding esophagogastroduodenoscopy than the original ALBI-PLT score (53.3% vs. 25.4%, p<0.01). Consistent results were observed in the validation cohort (28.4% vs. 15.4%, p<0.01), total cohort (40.8% vs. 20.4%, p<0.01), and cirrhotic cohort (32.2% vs. 11.5%, p<0.01). However, the missing ratio of patients with the HRV was not significantly increased in any cohort studied. Conclusion: Modification of the ALBI-PLT score may be useful for predicting patients without HRV.