TY - JOUR T1 - Possible Alterations in Appetite-related Molecules After the Elimination of Hepatitis C Virus JF - In Vivo JO - In Vivo SP - 1491 LP - 1496 DO - 10.21873/invivo.12856 VL - 36 IS - 3 AU - YOSHIHIRO SHIMONO AU - HIRAYUKI ENOMOTO AU - NOBUHIRO AIZAWA AU - TOMOYUKI TAKASHIMA AU - NAOTO IKEDA AU - YUKIHISA YURI AU - AOI FUJIWARA AU - KOHEI YOSHIHARA AU - RYOTA YOSHIOKA AU - SHOKI KAWATA AU - SHOGO OTA AU - RYOTA NAKANO AU - HIDEYUKI SHIOMI AU - TAKASHI NISHIMURA AU - HIROKO IIJIMA Y1 - 2022/05/01 UR - http://iv.iiarjournals.org/content/36/3/1491.abstract N2 - Background/Aim: Recent advances in antiviral treatment have achieved a sustained viral response (SVR) in over 95% of hepatitis C virus (HCV) infections. HCV elimination is suggested to improve several lifestyle-related factors; however, few studies have focused on dietary habit-/appetite-related factors. Patients and Methods: HCV-infected patients who received Daclatasvir/Asnaprevir (DCV/ASV) therapy were enrolled, and the changes in appetite-related molecules after antiviral therapy were assessed with a multiple cytokine-measuring system. Results: Among 119 HCV-infected patients who received DCV/ASV treatment, 104 (87.3%) achieved an SVR. In the SVR group, DCV/ASV treatment improved several liver-related variables at 24 weeks after the completion of therapy. In patients with an SVR, the values of glucagon-like peptide 1 (GLP-1) and leptin were significantly increased at 24 weeks after completing direct-acting antiviral therapy. However, no significant change was observed in non-SVR patients, regardless of the receipt of direct-acting antiviral treatment. Conclusion: Gastrointestinal hormones related to the dietary habit and/or appetite may be influenced by HCV elimination. ER -