RT Journal Article SR Electronic T1 Possible Alterations in Appetite-related Molecules After the Elimination of Hepatitis C Virus JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 1491 OP 1496 DO 10.21873/invivo.12856 VO 36 IS 3 A1 YOSHIHIRO SHIMONO A1 HIRAYUKI ENOMOTO A1 NOBUHIRO AIZAWA A1 TOMOYUKI TAKASHIMA A1 NAOTO IKEDA A1 YUKIHISA YURI A1 AOI FUJIWARA A1 KOHEI YOSHIHARA A1 RYOTA YOSHIOKA A1 SHOKI KAWATA A1 SHOGO OTA A1 RYOTA NAKANO A1 HIDEYUKI SHIOMI A1 TAKASHI NISHIMURA A1 HIROKO IIJIMA YR 2022 UL http://iv.iiarjournals.org/content/36/3/1491.abstract AB Background/Aim: Recent advances in antiviral treatment have achieved a sustained viral response (SVR) in over 95% of hepatitis C virus (HCV) infections. HCV elimination is suggested to improve several lifestyle-related factors; however, few studies have focused on dietary habit-/appetite-related factors. Patients and Methods: HCV-infected patients who received Daclatasvir/Asnaprevir (DCV/ASV) therapy were enrolled, and the changes in appetite-related molecules after antiviral therapy were assessed with a multiple cytokine-measuring system. Results: Among 119 HCV-infected patients who received DCV/ASV treatment, 104 (87.3%) achieved an SVR. In the SVR group, DCV/ASV treatment improved several liver-related variables at 24 weeks after the completion of therapy. In patients with an SVR, the values of glucagon-like peptide 1 (GLP-1) and leptin were significantly increased at 24 weeks after completing direct-acting antiviral therapy. However, no significant change was observed in non-SVR patients, regardless of the receipt of direct-acting antiviral treatment. Conclusion: Gastrointestinal hormones related to the dietary habit and/or appetite may be influenced by HCV elimination.