RT Journal Article SR Electronic T1 Complications of Trans-oral Endoscopic Thyroidectomy Vestibular Approach: A Systematic Review JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 1 OP 12 DO 10.21873/invivo.12671 VO 36 IS 1 A1 ELLADA AKRITIDOU A1 GERASIMOS DOURIDAS A1 ELEFTHERIOS SPARTALIS A1 GERASIMOS TSOUROUFLIS A1 DIMITRIOS DIMITROULIS A1 NIKOLAOS I. NIKITEAS YR 2022 UL http://iv.iiarjournals.org/content/36/1/1.abstract AB This review focuses on complications linked to trans-oral endoscopic thyroidectomy via vestibular approach (TOETVA) and aimed to elucidate the procedure’s initial safety profile. According to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA), Pubmed, Embase, and the Cochrane databases were screened till May 2021. Twenty-eight articles, nine cohorts and nineteen case series, met the inclusion criteria. Procedure-related complications were analyzed, the most important being hypoparathyroidism: transient (range=0.94-22.2%), permanent (range=1.33-2.22%), and recurrent laryngeal nerve injury: transient (range=1.9-8.8%) and permanent (range=0.59-1.42%). Surgical trauma related complications, the most prevalent being seroma, emphysema, and hematoma accounted for 2.91%. Null mortality was reported. Although current evolving experience indicates that TOETVA is safe and linked to acceptable complication rates, the method needs to be compared with the gold standard of traditional thyroidectomy in the context of sufficiently numbered cohorts and ultimately randomized controlled trials.