PT  - JOURNAL ARTICLE
AU  - EUN JI LEE
AU  - SOO JIN PARK
AU  - CHEOL LEE
AU  - GA WON YIM
AU  - JAE WEON KIM
AU  - HEE SEUNG KIM
TI  - Hypoxia-induced Maspin Expression Affects the Prognosis of Ovarian Clear Cell Carcinoma
AID  - 10.21873/invivo.12693
DP  - 2022 Jan 01
TA  - In Vivo
PG  - 212--220
VI  - 36
IP  - 1
4099  - http://iv.iiarjournals.org/content/36/1/212.short
4100  - http://iv.iiarjournals.org/content/36/1/212.full
SO  - In Vivo2022 Jan 01; 36
AB  - Background/Aim: To investigate the role of the expression of hypoxia-related genes on the prognosis of ovarian clear cell carcinoma (OCCC). Materials and Methods: Basal mRNA levels of eight hypoxia-related genes were compared. Cell viability was assayed after treating ES-2 cells under hypoxic conditions. The mRNA and protein levels were evaluated after the induction of hypoxia and administration of increased doses of N-acetylcysteine (NAC). Finally, the prognostic role of their expression levels was evaluated in 61 patients with OCCC. Results: The mRNA and protein levels of maspin increased gradually with the induction of hypoxia. Maspin protein expression decreased after treatment with paclitaxel and NAC. High expression of maspin was related to poor progression-free and overall survival in patients with OCCC (adjusted hazard ratios, 3.97 and 7.47; 95% confidence intervals=1.34-11.81, and 1.98-28.13). Conclusion: High expression of maspin induced by hypoxia might be associated with poor prognosis of OCCC.