TY - JOUR T1 - Histopathological Analysis of False-positive Lesions in mpMRI/TRUS Fusion Prostate Biopsy JF - In Vivo JO - In Vivo SP - 496 LP - 500 DO - 10.21873/invivo.12730 VL - 36 IS - 1 AU - RYOKEN YAMANAKA AU - YOHEI SEKINO AU - TAKASHI BABASAKI AU - KOHEI KOBATAKE AU - HIROYUKI KITANO AU - KENICHIRO IKEDA AU - KEISUKE GOTO AU - TETSUTARO HAYASHI AU - JUN TEISHIMA AU - YUKIO TAKESHIMA AU - YUKIKO HONDA AU - KAZUO AWAI AU - NOBUYUKI HINATA Y1 - 2022/01/01 UR - http://iv.iiarjournals.org/content/36/1/496.abstract N2 - Background/Aim: Multi-parametric magnetic resonance imaging (mpMRI)/ultrasonography fusion prostate biopsy (FB) is a more accurate method of diagnosis than conventional prostate biopsy, but false-positive lesions still exist. Limited studies have examined the cause of false-positive lesions by histological analysis. Patients and Methods: We examined 322 patients who underwent mpMRI/transrectal ultrasonography (TRUS) FB. We classified prostate imaging-recording and data system (PI-RADS) 3 and PI-RADS 4-5 as low PI-RADS lesions and high PI-RADS lesions, respectively. In total, 105 lesions were identified as false-positive lesions. We performed histological analysis of atrophy, hyperplasia, and lymphocyte infiltration in these lesions, comparing low PI-RADS lesions and high PI-RADS lesions. Results: The frequencies of prostate hyperplasia and lymphocyte infiltration were higher in high PI-RADS lesions than in low PI-RADS lesions (p=0.028 and 0.024, respectively). There was no significant difference regarding atrophy (p=0.295). Conclusion: Histopathological change may be one of the reasons for false-positive lesions. ER -